| SCF和APC/C的结构及功能 |
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| 引用本文： | 沈林海,陈加平,徐立红.SCF和APC/C的结构及功能[J].细胞生物学杂志,2007,29(4):487-492. |
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| 作者姓名： | 沈林海 陈加平 徐立红 |
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| 作者单位： | 浙江大学医学院生物化学与遗传学系，浙江大学医学院生物化学与遗传学系，浙江大学医学院生物化学与遗传学系 杭州310058，杭州310058 华中农业大学食品科学技术学院，武汉430070，杭州310058 |
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| 基金项目： | 浙江大学校科研和教改项目 |
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| 摘 要： | 细胞周期蛋白依赖性蛋白激酶(cyclin dependent kinases,CDKs)是细胞周期进行的推动力,泛素-蛋白酶体途径(ubiquitin-proteasome pathway,UPP)通过对细胞周期蛋白(cyclin)和CDK抑制物(CDK inhibitors,CKIs)的蛋白质水解作用来实现对CDKs活性的调控。SCF(Skp1-Cul1-F-box protein)和APC/C(anaphase-promoting complex/cyclosome)这两个泛素连接酶复合物参与了很多细胞周期调节因子的泛素化作用。它们参与的蛋白质降解系统的功能失调可能导致细胞增殖紊乱、基因组不稳定和肿瘤的发生。现对这两个泛素连接酶复合物的结构以及它们在细胞周期调控和肿瘤发生机制中的作用进行综述。
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| 关 键 词： | 细胞周期 肿瘤 |
| 修稿时间： | 2006-12-11 |
The Structure and Function of SCF and APC/C |
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| Lin-Hai Shen,Jia-Ping Chen,Li-Hong Xu.The Structure and Function of SCF and APC/C[J].Chinese Journal of Cell Biology,2007,29(4):487-492. |
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| Authors: | Lin-Hai Shen Jia-Ping Chen Li-Hong Xu |
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| Institution: | Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, China |
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| Abstract: | The cyclin-dependent kinases (CDKs) is a driving force of the cell cycle,and the activities of CDKs are controlled by the ubiquitin-proteasome pathway (UPP) through proteolysis of key regulators such as cyclins and CDK inhibitors. Two ubiquitin ligases,the Skp1-Cul1-F-box protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C),are responsible for the specific ubiquitylation of many regulators in cell cycle. Deregulation of the proteolytic system might result in uncontrolled proliferation,genomic instability and cancer. In this review,the structures of these two ubiquitin ligases and their functions in mechanisms of cell cycle control and cancer were summarized. |
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| Keywords: | SCF APC/C |
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