Polymorphic variants of <Emphasis Type="Italic">ALOX</Emphasis>5<Emphasis Type="Italic">AP</Emphasis> gene and the risk of acute stroke development in the Russian population |
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| Authors: | E A Bondarenko P A Slominsky S A Limborska I M Shetova D Yu Timofeev V I Skvortsova |
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| Institution: | 1.Institute of Molecular Genetics,Russian Academy of Sciences,Moscow,Russia;2.Research Institute of Cerebrovascular Pathology and Stroke,Russian State Medical University,Moscow,Russia |
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| Abstract: | The role of variants of the gene encoding arachidonate 5-lipoxygenase-activating protein (ALOX5AP) as possible susceptibility factors for acute stroke were examinated. Two ALOX5AP gene polymorphisms (SG13S114 (rs10507391) and SG13S32 (rs9551963)), which previously had shown association with the risk
of ischemic stroke in other populations, were studied. These single nucleotide polymorphisms were analyzed using a sample
of acute stroke patients (N = 1320) and a control sample (N = 467). No statistically significant associations were found between acute stroke and the ALOX5AP gene polymorphisms examined. |
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