Frequencies of the <Emphasis Type="Italic">DRB1</Emphasis>, <Emphasis Type="Italic">DQA1</Emphasis>, <Emphasis Type="Italic">DQB1</Emphasis> and <Emphasis Type="Italic">TNFA</Emphasis> alleles in immigrant population of west Siberia |
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| Authors: | O V Golovanova V I Konenkov A V Shevchenko M V Smolnikova |
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| Institution: | 1.Research Institute of Clinical and Experimental Lymphology,Russian Academy of Medical Sciences,Novosibirsk,Russia;2.Research Institute of Medical Problems of the North,Russian Academy of Medical Sciences,Krasnoyarsk,Russia |
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| Abstract: | Based on population analysis of the DRB1, DQA1, DQB1 and TNFA allele frequency distribution patterns, regional features of immunogenetic structure of the population of West Siberia were
investigated. Statistically significant linkage disequilibrium within the HLA class II region, as well as between the TNFA and DRB1, DQA1, and DQB1 was demonstrated. Population frequency distribution patterns of two- and multilocus haplotypes were examined. |
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