Association of β-fibrinogen gene ?148C/T and ?455G/A polymorphisms and coronary artery disease in Chinese population: A Meta analysis |
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Authors: | XiaoChao Chen MingTong Xu LiZi Jin Jian Chen WeiQing Chen |
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Institution: | (1) Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Riad El Solh, P.O. Box 11-0236, Beirut, 1107 2020, Lebanon;(2) Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon; |
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Abstract: | The purpose of our study was to evaluate the correlation between the β-fibrinogen gene −148C/T and −455G/A polymorphisms and
susceptibility to coronary artery disease in the Chinese population using a meta-analytic approach. Eligible studies about
this correlation were identified by searching the PubMed, EMBASE, and CNKI databases. Of the 13 identified, 7 (with 1488 cases
and 1234 controls) involved the −148C/T polymorphism and 9 (with 1023 cases and 1081 controls) involved the −455G/A polymorphism.
No publication bias was detectable and heterogeneity testing found significant differences between the ORs for both groups
of studies. The combined OR for the 7 studies on susceptibility to coronary artery disease in −148T allele carriers compared
to the −148C/C wild-type homozygotes was 1.31 (95%CI: 0.94–1.84, P=0.11). The combined OR for the 9 studies on susceptibility to coronary artery disease in −455A allele carriers compared to
the −455G/G wild-type homozygotes was 1.75 (95%CI: 1.24–2.46, P=0.001). Our results suggest the absence of an association between the β-fibrinogen gene −148C/T polymorphism and susceptibility
to coronary artery disease and the possibility that −455G/A polymorphism (in particular, allele A) increases susceptibility
to this disease in the Chinese population. |
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