The mycobacterial DNA-binding protein 1 (MDP1) from <Emphasis Type="Italic">Mycobacterium bovis</Emphasis> BCG influences various growth characteristics |
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| Authors: | Astrid Lewin Daniela Baus Elisabeth Kamal Fabienne Bon Ralph Kunisch Sven Maurischat Michaela Adonopoulou Katharina Eich |
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| Institution: | 1.Robert-Koch-Institut,Berlin,Germany;2.Sanofi-Aventis Germany GmbH,TD Metabolism,Frankfurt am Main,Germany;3.IUT de Dijon, Département Génie Biologique,Bd Dr Petitjean,Dijon Cedex,France;4.Klinik für Allgemein-, Visceral- und Transplantations-Chirurgie,Charité-Campus Virchow,Berlin,Germany |
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| Abstract: | Background Pathogenic mycobacteria such as M. tuberculosis, M. bovis or M. leprae are characterised by their extremely slow growth rate which plays an important role in mycobacterial virulence and eradication
of the bacteria. Various limiting factors influence the generation time of mycobacteria, and the mycobacterial DNA-binding
protein 1 (MDP1) has also been implicated in growth regulation. Our strategy to investigate the role of MDP1 in mycobacterial
growth consisted in the generation and characterisation of a M. bovis BCG derivative expressing a MDP1-antisense gene. |
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