Pongamone A-E, five flavonoids from the stems of a mangrove plant, Pongamia pinnata |
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Authors: | Li Liya Li Xiang Shi Cui Deng Zhiwei Fu Hongzheng Proksch Peter Lin Wenhan |
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Institution: | The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, PR China. |
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Abstract: | Chemical investigation of stems of the mangrove plant, Pongamia pinnata, resulted in isolation and characterization of five structurally unusual flavonoids pongamones A-E, along with 16 known flavonoid metabolites. Their structures were determined on the basis of spectroscopic analyses and by comparison of their spectroscopic data with those of related compounds reported in the literature. Pongamones A-E were assayed against DHBV RCs DNAP and HIV-1 RT in vitro. A possible biogenetic pathway of the isolated compounds is also proposed. |
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Keywords: | Mangrove plant Pongamia pinnata Leguminosae Flavonoids Pongamones A-E Structure elucidation |
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