Effect of monoamine oxidase inhibitors on the labeling of subcellular fractions of brain and liver by 14C-serotonin
Affiliation:
1. Université de Bordeaux, Bordeaux, France;2. Inserm U1215, Neurocentre Magendie, Physiopathology of Addiction and Traumatic Memories Group, Bordeaux, France;1. CERVO Brain Research Centre, Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada;2. Departments of Pathology & Cell Biology and of Physiology, Groupe de recherche sur le système nerveux central (GRSNC), Faculty of Medicine, Université de Montréal, Montreal, QC, Canada;1. Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, United States;2. Department of Pharmacology and Toxicology, The Jacobs School of Medicine and Biomedical Sciences University at Buffalo, Buffalo, NY, United States
Abstract:
We recently observed that under certain conditions, radioactivity from labeled serotonin becomes firmly associated with acid-insoluble material obtained from mitochondrial preparations. This association is prevented by MAO-inhibitors3 (Alivisatos et al role=presentation style=font-size: 90%; display: inline-block; position: relative;>, 1966a). A preliminary report of our observations on the mechanism and the potential significance of such associations is presented here.
