Next-generation Interactomics: Considerations for the Use of Co-elution to Measure Protein Interaction Networks期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Next-generation Interactomics: Considerations for the Use of Co-elution to Measure Protein Interaction Networks

Institution:	3. Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada;4. Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada

Abstract:	Download : Download high-res image (64KB) Download : Download full-size image Highlights •Co-elution stands out as a global interactome mapping method. •Benefits include all-to-all protein analysis and measurement of interactome perturbations. •Different separation, quantification and bioinformatic strategies are available. •Design considerations depend largely on system under study.

Keywords:	Protein-protein interactions protein complex analysis separation technologies mass spectrometry chromatography bioinformatics SILAC co-elution co-fractionation complexes interactome protein correlation profiling
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