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Single-cell Proteomics: Progress and Prospects

Institution:	Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA

Abstract:	Download : Download high-res image (315KB) Download : Download full-size image Highlights •Label-free and isobaric labeling approaches for in-depth profiling of single cells. •Miniaturization and simplification of sample processing reduce surface losses. •Nanoflow separations enhance ionization efficiency and reduced chemical noise. •Ultrasensitive mass spectrometry and gas-phase separation add selectivity.

Keywords:	Cell biology Cell sorting Label-free quantification Mass Spectrometry Tandem Mass Spectrometry Tissues* FAIMS nanoLC nanoPOTS single-cell ultrasensitive
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