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Disulfiram and Its Copper Chelate Attenuate Cisplatin-Induced Acute Nephrotoxicity in Rats Via Reduction of Oxidative Stress and Inflammation |
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| Authors: | Khairnar Shraddha I. Mahajan Umesh B. Patil Kalpesh R. Patel Harun M. Shinde Sachin D. Goyal Sameer N. Belemkar Sateesh Ojha Shreesh Patil Chandragouda R. |
| Affiliation: | 1.Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, Maharashtra, 425405, India ;2.Department of Pharmacology, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, Maharashtra, 425405, India ;3.Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule, Maharashtra, 425405, India ;4.Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, Maharashtra, 424001, India ;5.Department of Pharmacology, School of Pharmacy & Technology Management, SVKM’s NMIMS, Shirpur, India, Shirpur, Dist. Dhule, Maharashtra, 425405, India ;6.Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, Abu Dhabi, United Arab Emirates ; |
| Abstract: | Biological Trace Element Research - The use of cisplatin (CP) in chemotherapy of resistant cancers is limited due to its dose-dependent nephrotoxicity. Disulfiram (DSF), the aversion therapy for... |
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