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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
Affiliation:1. Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, South Korea;2. Department of Integrated OMICS for Biomedical Science, Yonsei University, Seoul 03722, South Korea;3. Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul 03759, South Korea;4. Research Institute of National Cancer Center, Goyang-si, Gyeonggi-do 10408, South Korea;5. Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, South Korea;6. Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Chungbuk 28116, South Korea
Abstract:
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  • Keywords:glutamine  SLC1A5 variant  mitochondrial glutamine transporter  metabolic reprogramming  hypoxia  HIF-2α  gemcitabine resistance  ASCT2  SLC1A5  cancer metabolism
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