| FK-506结合蛋白对钙释放通道的调控 |
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| 引用本文： | 孙俊辉,朱培闳.FK-506结合蛋白对钙释放通道的调控[J].生物化学与生物物理进展,1997,24(5):418-422. |
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| 作者姓名： | 孙俊辉 朱培闳 |
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| 作者单位： | 中国科学院上海生理研究所, 上海 200031;中国科学院上海生理研究所, 上海 200031 |
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| 摘 要： | 细胞内自由钙作为一种重要的细胞信使广泛地参与细胞生理功能调控.胞内钙库(内质网系和肌浆网系)对调节细胞内自由钙水平起着重要的作用.钙库膜上的钙释放通道(ryanodine受体和三磷酸肌醇受体)受许多因素调控，其中之一就是新近研究得相当多的FK506结合蛋白.免疫抑制剂FK506能特异地结合钙库上一种分子质量为12 ku左右的蛋白，这种FK506结合蛋白与钙释放通道形成一种紧密连接的复合体，在正常生理情况下对钙释放通道起着十分重要的调控作用.
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| 关 键 词： | 胞浆自由钙，钙释放通道，FK506，FK506结合蛋白，细胞信号转导 |
| 收稿时间： | 1996/8/26 0:00:00 |
| 修稿时间： | 1997/3/10 0:00:00 |
Modulation of Calcium Release Channels by FK506-binding Protein |
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| SUN Junhui and ZHU Peihong.Modulation of Calcium Release Channels by FK506-binding Protein[J].Progress In Biochemistry and Biophysics,1997,24(5):418-422. |
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| Authors: | SUN Junhui and ZHU Peihong |
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| Institution: | Shanghai Institute of Physiology, The Chinese Academy of Sciences, Shanghai 200031, China;Shanghai Institute of Physiology, The Chinese Academy of Sciences, Shanghai 200031, China |
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| Abstract: | As an important messenger, intracellular free calcium can modulate many cellular functions. Calcium stores, endoplasmic reticulum and sarcoplasmic reticulum, play important functions in controlling the level of intracellular calcium. The activities of calcium release channel on these calcium stores, ryanodine receptor and inositol trisphosphate receptor, are affected by several factors. FK506, an immunosuppressive drug, can specifically bind to a cytosolic receptor with molecular weight of about 12 ku, namely, FK506-binding protein (FKBP12). In vivo, FKBP12 maintains a tight association with calcium release channel and forms a complex. This interaction plays important roles in modulating calcium release channels. |
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| Keywords: | cytosolic free calcium calcium release channel FK506 FK506-binding protein cellular signal transduction |
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