Homology between a 173-kb Region from Mouse Chromosome 10, Telomeric to the Ifng Locus, and Human Chromosome 12q15 |
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Authors: | Soline Vigneau Florence Levillayer Herv Crespeau Laurence Cattolico Bernard Caudron Franck Bihl Catherine Robert Michel Brahic Jean Weissenbach Jean-Franois Bureau |
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Institution: | Unité des Virus Lents (CNRS URA 1930), Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France. |
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Abstract: | We sequenced a 173-kb region of mouse chromosome 10, telomeric to the Ifng locus, and compared it with the human homologous sequence located on chromosome 12q15 using various sequence analysis programs. This region has a low density of genes: one gene was detected in the mouse and the human sequences and a second gene was detected only in the human sequence. The mouse gene and its human orthologue, which are expressed in the immune system at a low level, produce a noncoding mRNA. Nonexpressed sequences show a higher degree of conservation than exons in this genomic region. At least three of these conserved sequences are also conserved in a third mammalian species (sheep or cow). |
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Keywords: | Abbreviations: comparative genome sequence analysisAbbreviations: mouse chromosome 10Abbreviations: interferon-γAbbreviations: noncoding mRNAAbbreviations: conserved nonexpressed sequences |
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