Nuclear translocation of proteins and the effect of phosphatidic
acid |
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Authors: | Hongyan Yao Geliang Wang Xuemin Wang |
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Institution: | 1.National Key Laboratory of Plant Molecular
Genetics; Institute of Plant Physiology and Ecology; Chinese Academy of
Sciences; Shanghai, China;2.Department of Biology; University of Missouri;
St. Louis, MO USA; Donald Danforth Plant Science Center; St. Louis, MO USA |
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Abstract: | Transport of proteins containing a nuclear localization signal (NLS) into the nucleus is
mediated by nuclear transport receptors called importins, typically dimmers of a
cargo-binding α-subunit and a β-subunit that mediates translocation through the
nuclear pore complexes (NPCs). However, how proteins without canonical NLS move into the
nucleus is not well understood. Recent results indicate that phospholipids, such as
phosphatidic acid, play important roles in the intracellular translocation of proteins
between the nucleus and cytoplasm. |
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Keywords: | Arabidopsis nuclear localization signal protein nuclear import phospholipid phosphatidic acid |
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