Mapping of the variegate porphyria (VP) gene: Contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32 |
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| Authors: | Louise Warnich Peter N Meissner Richard J Hift Jan H Louw Carel J van Heerden Andries E Retief |
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| Institution: | (1) Department of Genetics, University of Stellenbosch, Stellenbosch, Private Bag X1, Matieland, 7602, South Africa Fax: +27-21-8084336 e-mail: lw@maties.sun.ac.za, ZA;(2) MRC Liver Research Unit, Department of Medicine, University of Cape Town, Observatory, South Africa, ZA |
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| Abstract: | The gene for variegate porphyria (VP), an autosomal dominant disease with a high prevalence in South Africa, evidently due
to a founder effect, was previously mapped to chromosome 14q32. In the current study this localization was evaluated by linkage
and haplotype analyses using microsatellite markers spanning a region of more than 20 cM on chromosome 14q32. In many recent
studies linkage disequilibrium between disease and marker loci has been utilized to map genes in founder populations, but
we could not find any association between VP and the markers used in this study. Our data suggest that the allocation of VP
to chromosome 14q32 may be incorrect.
Received: 1 September 1995 / Revised: 1 November 1995 |
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