Trypsin-like activity of rat anterior pituitary in relation to secretory activity. |
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| Authors: | A Kenessey P Páldi-Haris G B Makara L Graf |
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| Affiliation: | 1. Institute for Drug Research, H-1325 Budapest, P.O. Box 82, Hungary;2. Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary |
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| Abstract: | Biochemical changes in trypsin-like activity were studied in rat anterior pituitary during experimentally induced changes of hormone secretion. While dexamethasone and ACTH treatment of female rats led to a significant decrease of adenohypophyseal trypsin-like activity, elevated enzyme activity was observed after adrenalectomy and ovariectomy. This correlation together with our previous data on the subcellular localisation and some biochemical properties of the trypsin-like proteinases in the anterior pituitary suggests that these enzymes may be involved in the biosynthesis of some polypeptide hormones. |
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