The estrogenic activity of DDT: and induction of a specific estrogen inducible uterine protein by o,p'-DDT |
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Authors: | George M Stancel Judy S Ireland Venkat R Mukku Alice K Robison |
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Institution: | Department of Pharmacology The University of Texas Medical School at Houston Houston, Texas 77025, USA |
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Abstract: | The pesticide o,p'-DDT stimulates the production of a specific uterine protein, the so-called induced protein or IP, normally associated with an estrogenic response of the uterus. stimulation of IP production is observed 1 hour after the administration of 250 mg/kg of o,p'-DDT to immature rats. stimulation of IP production is observed after a 1 hour incubation of uteri with 100 μM o,p'-DDT. This response is blocked by Actinomycin D. In contrast to o,p'-DDT, which binds to the cytoplasmic estrogen receptor and stimulates IP production, p,p'-DDT which does not bind well to the estrogen receptor does not stimulate IP production . These findings represent the first report of an estrogenic effect of o,p'-DDT in a completely system. |
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