Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart |
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| Authors: | S Saeki F Masugi T Ogihara A Otsuka Y Kumahara K Watanabe K Tamura A Akashi A Kumagai |
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| Affiliation: | 1. Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, Osaka 553 Japan;1. Research Institute, Daiichi Seiyaku Co., Ltd., Edogawa-ku, Tokyo 134 Japan |
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| Abstract: | ![]()
The direct cardiac action of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) was studied in isolated perfused guinea-pig heart preparations. PAF produced a fall in left ventricular pressure, decreases in the rate of rise of the left ventricular pressure (dp/dt) and coronary flow, but had no effect on heart rate. These results indicate that PAF is a cardiodepressant with inotropic selectivity and this effect on heart is blocked by CV-3988, a specific PAF antagonist. |
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