Ultrastructural analysis of mineralized matrix from human osteoblastic cells: Effect of tumor necrosis factor-alpha |
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Authors: | Panagakos Fotinos S Fernandez Cesar Kumar Suriender |
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Institution: | (1) Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, 160 012 Chandigarh, India |
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Abstract: | The study, addressed to understand whether or not human platelets possess a unique thiol-oxidase whose activity could be modulated by signalling pathway initiated upon the activation of Receptor-Ck revealed the existence of disulphide-dependent oxidation within these cells and this phenomenon was regulated by Receptor-Ck-dependent generation of second messengers especially phosphatidic acid (PA); cAMP and cGMP. Purification of this activity revealed the existence of 47 kDa protein having thiol-oxidase activity. Keeping in view these results we propose that the existence of this novel 47 kDa Thiol-oxidase within human platelets may provide a crucial switch for the regulation of Receptor-Ck-dependent mevalonate pathway in human platelets. |
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Keywords: | cholesterol Receptor-Cgif" alt="lsquo" align="BASELINE" BORDER="0">Ck" target="_blank">gif" alt="rsquo" align="BASELINE" BORDER="0">k thiol-oxidase platelets |
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