| 小青龙汤对小鼠支气管哮喘模型气道炎症及细胞因子的影响 |
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| 引用本文： | 罗丹冬,丘振文.小青龙汤对小鼠支气管哮喘模型气道炎症及细胞因子的影响[J].现代生物医学进展,2010,10(4). |
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| 作者姓名： | 罗丹冬 丘振文 |
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| 作者单位： | 广州中医药大学第一附属医院,广东,广州,510405 |
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| 摘 要： | 目的:探讨中药方剂小青龙汤对小鼠哮喘模型气道炎症及细胞因子的影响。方法:40只BALB/c小鼠随机分为正常对照组(A组)、哮喘模型组(B组)、小青龙汤低剂量组(C组)和小青龙汤高剂量组(D组)。B、C、D组采用卵蛋白(OVA)腹腔注射致敏与雾化吸入激发制作哮喘模型。于OVA激发结束后24h收集支气管肺泡灌洗液(BALF)计数炎性细胞总数及嗜酸性粒细胞(EOS)数目,并测定BALF上清液中白细胞介素-4(IL-4)和干扰素-γ(IFN-γ)水平变化。结果:小青龙汤的干预治疗能显著降低小鼠BALF中炎性细胞总数及EOS数量;BALF上清液中IFN-γ水平明显升高,IL-4水平显著下降。D、C组与A组、B组有显著性差异(P<0.05),C组与D组结果亦存在显著性差异(P<0.05)。结论:小青龙汤能明显降低哮喘小鼠BALF中炎性细胞数量,影响细胞因子水平变化,从而改善哮喘气道炎症。
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| 关 键 词： | 小青龙汤 哮喘模型 气道炎症 细胞因子 |
Effect of Xiaoqinglong decoction on airway inflammation and cytokine in a mouse asthmatic model |
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| LUO Dan-dong,QIU Zhen-wen.Effect of Xiaoqinglong decoction on airway inflammation and cytokine in a mouse asthmatic model[J].Progress in Modern Biomedicine,2010,10(4). |
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| Authors: | LUO Dan-dong QIU Zhen-wen |
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| Institution: | LUO Dan-dong,QIU Zhen-wen (The First Clinical Medical College of Guangzhou University of TCM,Guangzhou 510405,China) |
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| Abstract: | Objective: To explore the effect of Xiaoqinglong decoction on the airway inflammation and the cytokine production in asthmatic mice. Methods: Forty BALB/c mice were divided into four groups including a control group ( group A), an asthmatic model group (group B), low dose of Xiaoqinglong decoction group ( group C) and high dose of Xiaoqinglong decoction group (group D). Asthma mouse models in group B, group C and group D were prepared by injecting ovalbumin ( OVA ) into the abdominal cavity and inhalation o... |
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| Keywords: | Xiaoqinglong decoction Asthmatic model Airwayinflammation Cytokines |
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