Perfusion rate dependent prostaglandin release from isolated rabbit kidneys |
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Authors: | Uffe Bang Olsen |
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Institution: | Department of Pharmacology, Leo Pharmaceutical Products, 2750 Ballerup, Denmark |
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Abstract: | Isolated rabbit kidneys were perfused with 37°C Krebs-Henseleit solution aerated with 95% O2 + 5% CO2. Perfusion rate was varied from 1 to 10 ml/min. This was accompanied by parallel changes of perfusion pressure, prostaglandin excretion and release of radioactivity from kidneys with 14C-arachidonic acid incorporated into the tissue lipid pool. It is suggested that enhancement of perfusion rate raises the intrarenal pressure which increases renal prostaglandin release due to increased substrate availability. |
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