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Sphingomyelin is associated with kidney disease in type 1 diabetes (The FinnDiane Study) |
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| Authors: | Ville-Petteri M?kinen Tuulia Tynkkynen Pasi Soininen Carol Forsblom Tomi Peltola Antti J Kangas Per-Henrik Groop Mika Ala-Korpela |
| Institution: | 1. Computational Medicine Research Group, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, 90014, Oulu, Finland 2. Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland 3. NMR Metabonomics Laboratory, Department of Biosciences, University of Eastern Finland, Kuopio, Finland 4. Folkh?lsan Research Center, Folkh?lsan Institute of Genetics, Biomedicum, Helsinki, Finland 5. Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland 6. Department of Biomedical Engineering and Computational Science, School of Science and Technology, Aalto University, Helsinki, Finland |
| Abstract: | Diabetic kidney disease, diagnosed by urinary albumin excretion rate (AER), is a critical symptom of chronic vascular injury in diabetes, and is associated with dyslipidemia and increased mortality. We investigated serum lipids in 326 subjects with type 1 diabetes: 56% of patients had normal AER, 17% had microalbuminuria (20?≤?AER? |
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