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Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction
Authors:Figueroa-Perez Ignacio  Stadelmaier Andreas  Deininger Susanne  Aulock Sonja von  Hartung Thomas  Schmidt Richard R
Affiliation:Fachbereich Chemie, Universit?t Konstanz, Fach M 725, D-78457 Konstanz, Germany.
Abstract:For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.
Keywords:Bacteria   Gram-positive   Lipoteichoic acid   Synthesis   Modifications
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