Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction |
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Authors: | Figueroa-Perez Ignacio Stadelmaier Andreas Deininger Susanne Aulock Sonja von Hartung Thomas Schmidt Richard R |
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Affiliation: | Fachbereich Chemie, Universit?t Konstanz, Fach M 725, D-78457 Konstanz, Germany. |
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Abstract: | For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies. |
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Keywords: | Bacteria Gram-positive Lipoteichoic acid Synthesis Modifications |
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