Chromosomal Localization of Three Human Dual Specificity Phosphatase Genes (DUSP4, DUSP6, and DUSP7) |
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| Authors: | Anna Smith Cathy Price Martin Cullen Marco Muda Andrea King Bradford Ozanne Steve Arkinstall Alan Ashworth |
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| Institution: | aCancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, United Kingdom;bGeneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A. CH-1228 Plan-les-Ouates, Geneva, Switzerland;cCancer Research Campaign Laboratories, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, United Kingdom |
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| Abstract: | Mitogen-activated protein (MAP) kinase phosphatases constitute a growing family of dual specificity phosphatases thought to play a role in the dephosphorylation and inactivation of MAP kinases and are therefore likely to be important in the regulation of diverse cellular processes such as proliferation, differentiation, and apoptosis. For this reason it has been suggested that MAP kinase phosphatases may be tumor suppressors. We have determined the chromosomal locations of three human dual specificity phosphatase genes by fluorescencein situhybridization and radiation hybrid mapping. The genes were localized to three different chromosomes,MKP2(DUSP4) to 8p11–p12,MKP3(DUSP6) to 12q22–q23, andMKPX(DUSP7) to 3p21. This will allow the potential roles of these genes in disease processes to be evaluated. |
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