Automation of functional assays by flow injection fluorescence microscopy. |
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| Authors: | L D Scampavia P S Hodder I L?hdesm?ki J Ruzicka |
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| Affiliation: | Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA. scamp@u.washington.edu |
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| Abstract: | Bead-injection spectroscopy is a novel technique that uses immobilized eukaryotic cells on microbeads as a renewable biosensor for fluorescence microscopy. The use of a flow injection instrument allows fast functional assays that generate full kinetic characterization of a drug. Because the cell population is automatically replaced for each assay, variability is minimized, thus allowing greater accuracy. |
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