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| S100蛋白功能和结构研究进展 | |
| 引用本文： | 李国明,戴克胜,李天才. S100蛋白功能和结构研究进展[J]. 生物技术通报, 2011, 0(6) |
| 作者姓名： | 李国明 戴克胜 李天才 |
| 作者单位： | 1. 北京航空航天大学生物与医学工程学院,北京,100191 2. 中国科学院西北高原生物研究所,西宁,810008 |
| 摘 要： | S100蛋白作为Ca2+调节蛋白广泛存在于各种脊椎动物中.它们参与调控蛋白磷酸化、酶活性、细胞增殖分化、细胞骨架组成的动力学、膜结构组成、维持细胞间Ca2+浓度的恒定、参与炎症反应,以及保护细胞免受氧化损伤等.对S100蛋白的一般特征、细胞内外的功能及结构的研究进展等方面做了比较全面的阐述.部分S100蛋白三维结构的解析为进一步探讨其功能提供了直观的信息. |
| 关 键 词： | S100蛋白 钙离子 功能 结构 |
Progress in S100 Proteins Function and Structure |
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| Li Guoming,Dai Kesheng,Li Tiancai. Progress in S100 Proteins Function and Structure[J]. Biotechnology Bulletin, 2011, 0(6) | |
| Authors: | Li Guoming Dai Kesheng Li Tiancai |
| Affiliation: | Li Guoming~1 Dai Kesheng~1 Li Tiancai~2 (1 School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,2 Northwest Institute of Plateau Biology,Chinese Academy of Science,Xining 810008) |
| Abstract: | S100 proteins are Ca~(2+)sensor proteins and expressed in vertebrates exclusively.They play important roles in the Ca~(2+)- dependent regulation of protein phosphorylation,enzyme activities,the inflammatory response,Ca~(2+)homeostasis,the dynamics of cytoskeleton constituents,and cell proliferation and differentiation.This review summarized the progress achieved in the functional and structural studies of S100 proteins.Determination of the structures of some S100 proteins helps us to further understand the ... |
| Keywords: | S100 proteins Ca~(2 ) Function Structure |
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