Histochemical characterization of the lead intranuclear inclusion bodies |
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Authors: | Bashir M Jarrar Zuhair N Mahmoud |
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Institution: | (1) Department of Zoology, College of Science, King Saud University, P. O. Box 2455, 11451 Riyadh, Saudi Arabia;(2) Department of Zoology, Faculty of Science, University of Khartoum, P. O. Box 321, Khartoum, Sudan |
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Abstract: | A battery of histological and histochemical techniques was applied on the lead intranuclear bodies that have resuted in the
kidneys of adult Wistar male rats receiving lead acetate in their diet to determine their nature. The intranuclear inclusion
bodies have stained strongly with xanthene, anthraquinone, and trisulfonated basophilic dyes and weakly with dyes containing
both positive and negative radicals, and they have responded negatively to acidophilic cationic dyes. They have also reacted
positively to proteins and lead stains, but weakly to lipid stains, and negatively to Feulgen and methyl green pyronin techniques.
The intranuclear bodies proved to be lead lipoprotein complexes containing sulfyhydryl groups and are basic in nature with
orthochromatic, eosinophilic, argyrophilic, osmophilic, fuchsinophilic, and sudanophilic characteristics. |
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Keywords: | Lead intranuclear bodies histochemistry rat |
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