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Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry
Authors:Mariaelisa Graff  Anne E Justice  Kristin L Young  Eirini Marouli  Xinruo Zhang  Rebecca S Fine  Elise Lim  Victoria Buchanan  Kristin Rand  Mary F Feitosa  Mary K Wojczynski  Lisa R Yanek  Yaming Shao  Rebecca Rohde  Adebowale A Adeyemo  Melinda C Aldrich  Matthew A Allison  Christine B Ambrosone  Kari E North
Institution:1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;2. Population Health Services, Geisinger Health, Danville, PA 17822, USA;3. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK;4. Centre for Genomic Health, Life Sciences, Queen Mary University of London, London EC1M 6BQ, UK;5. Vertex Pharmaceuticals Inc., Boston, MA 02210, USA;6. Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA;7. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;8. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA;9. Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;10. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA;11. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;12. Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;13. Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA;14. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA 92093, USA;15. Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;16. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA;17. Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;18. School of Public Health, University of Kentucky, Lexington, KY 40563, USA;19. Framingham Heart Study, Boston University School of Medicine, Boston, MA 02118, USA;20. Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA;21. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA;22. Department of Biostatistics, University of Washington, Seattle, WA 98195, USA;23. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA;24. Division of Biomarkers of Early Detection and Prevention, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA;25. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA;26. International Epidemiology Institute, Rockville, MD 20850, USA;27. The Charles R. Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;28. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;29. Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;30. Center for Diabetes Research, Wake Forest school of Medicine, Winston-Salem, NC 27157, USA;31. Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;32. Department of Pediatrics, Section of Genomic Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA;33. Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA;34. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, USA;35. Harvard Medical School, Boston, MA 02115, USA;36. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;37. Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;38. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA;39. Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;40. Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA;41. Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA;42. Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;43. Cancer Prevention Institute of California, Fremont, CA 94538, USA;44. Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, LA 90033, USA;45. Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA;46. Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA;47. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA;48. Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;49. Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA;50. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;51. Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA;52. Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria;53. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA;54. Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA;55. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA;56. Framingham Heart Study, Framingham, MA 01702, USA;57. Division of Endocrinology and Metabolism, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;58. Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;59. National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA;60. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA;61. SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;62. Center for Spatial and Functional Genomics, The Children’s Hospital of Philadelphia Research Institute, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;63. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA;64. Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA;65. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA;66. Department of Preventive Medicine, Stony Brook University, Stony Brook, NY 11794, USA;67. Chronic Disease Research Centre and Faculty of Medical Sciences, University of West Indies, Bridgetown, Barbados;68. Ministry of Health, Bridgetown, Barbados;69. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA;70. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;71. Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA 02115, USA;72. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;73. Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community Implementation and Dissemination Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;74. MedStar Research Institute, Hyattsville, MD 20782, USA;75. Department of Medicine, Stanford Prevention Research Center and Cancer Institute, Stanford, CA 94305, USA;76. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA;77. Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA;78. Department of Public Health Sciences, University of Chicago, Chicago, IL 60637, USA;79. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA;80. Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA 94304, USA;81. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA;82. Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;83. Genetic Epidemiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA;84. Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA;85. Division of Health Equities, Department of Population Sciences, City of Hope Medical Center, Duarte, CA 91010, USA;86. Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA;87. Epidemiology Program, Cancer Research Center, University of Hawaii Cancer Center, Honolulu, HI 96813, USA;88. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA;89. Sickle Cell Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA;90. Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA;91. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;92. Data Tecnica Int’l, LLC, Glen Echo, MD 20812, USA;93. Montreal Heart Institute, Montréal, QC H1T 1C8, Canada;94. Department of Medicine, Université de Montréal, Montréal, QC H1T 1C8, Canada;95. Department of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA;96. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;97. Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;98. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA;99. Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA;100. Department of Epidemiology, Brown University, Providence, RI 02912, USA;101. Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA;102. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;103. The Center for Observational Research, Amgen, Inc., Thousand Oaks, CA 91320, USA;104. Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA;105. Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA;106. Department of Urology, Northwestern University, Chicago, IL 60611, USA;107. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;108. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA;109. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA;110. Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria;111. Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria;112. Centre for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria;113. Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL 60637, USA;114. Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI 48202, USA;115. Slone Epidemiology Center, Boston University School of Medicine, Boston, MA 02118, USA;116. Department of Biochemistry, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA;117. Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA;118. Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA;119. Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;120. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA;121. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;122. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA;123. Department of Family and Community Medicine, Meharry Medical College, Nashville, TN 37208, USA;124. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;125. Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA;126. Karmanos Cancer Institute, Detroit, MI 48201, USA;127. The New York Academy of Medicine, New York, NY 10029, USA;128. Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, MI 48109, USA;129. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA;130. Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA;131. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA;132. Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40202, USA;133. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA;134. Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;135. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA;136. Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA;137. Departments of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA;138. Department of Internal Medicine, Henry Ford Health System, Detroit, MI 48202, USA;139. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA;140. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA;141. Department of Urology, University of California, San Francisco, San Francisco, CA 94158, USA;142. Division of Gastroenterology, Hepatology and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19146, USA;143. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK;144. School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA;145. BioData Catalyst Program, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA;146. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;147. The Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Abstract:
Keywords:African ancestry  height  genome-wide  fine-mapping
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