The peracid cleavage of 5-methyltetrahydrofolic acid at the C9-N10 bridge. |
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| Authors: | C M Baugh E B Braverman M G Nair D W Horne W T Briggs C Wagner |
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| Institution: | 1. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232 USA;2. Veterans'' Administration Hospital, Nashville, Tennessee 37232 USA |
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| Abstract: | 5-Methyltetrahydrofolate cannot be cleaved at the C9N10 bond by the zinc/HCl reductive or the permanganate oxidative cleavage methods. A new method has been developed to perform this cleavage, using peracetic acid in 50% trifluoroacetic acid; the cleavage is quantitative and nondestructive of γ-glutamyl peptide bonds. |
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