Sertoli cells from immature rats : in vitro stimulation of steroid metabolism by FSH. |
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Authors: | M J Welsh J P Wiebe |
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Institution: | Regulatory Mechanisms Laboratory, Department of Zoology, University of Western Ontario, London, Ontario, Canada N6A 5B7 |
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Abstract: | Sertoli cells from 10 day old rats convert androstenedione to testosterone and 5α-androstane-3α,17β-diol, testosterone to 17β-hydroxy-5α-androstan-3-one and 5α-androstane-3α,17β-diol, and 17β-hydroxy-5α-androstan-3-one to 5α-andro-stane-3α,17β-diol after 72 hours . Conversions of androstenedione to testosterone and 5α-androstane-3α,17β-diol, and testosterone to 5α-androstane-3α,17β-diol were 2 to 3 times greater in FSH treated cultures. Steroid conversion was not stimulated significantly by LH or TSH. The results are interpreted as evidence that in young rats Sertoli steroid metabolism is stimulated by FSH, that Sertoli cells are an androgen target and that FSH may induce or facilitate Sertoli androgen responsiveness. |
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Keywords: | FSH follicle-stimulating hormone LH luteinizing hormone TSH thyroid stimulating hormone A androstenedione T testosterone DHT 17β-hydroxy-5α-androstan-3-one DIOL 5α-androstane-3α 17β-diol |
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