Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum |
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| Authors: | Hegde Vinod R Pu Haiyan Patel Mahesh Black Todd Soriano Aileen Zhao Wenjun Gullo Vincent P Chan Tze-Ming |
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| Affiliation: | Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hedge@spcorp.com |
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| Abstract: | ![]()
The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC(50) of 4 and 5 microM, respectively. |
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