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Antitumour activities of levans produced by Zymomonas mobilis strains |
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| Authors: | GMT Calazans CE Lopes RMOC Lima FP de Franc¸a |
| Affiliation: | (1) Departamento de Antibio´ticos, Universidade Federal de Pernambuco Cidade Universita´ria, 50670–901 Recife PE, Brazil;(2) Depto de Engenharia Bioqui´mica, Escola de Qui´mica, Universidade Federal do Rio de Janeiro-Centro de Tecnologia, Bloco E Ilha do Fundão, 21941-900 Rio de Janeiro RJ, Brazil |
| Abstract: | Levans produced by four Zymomonas mobilis strains showed antitumour activity against sarcoma 180 and Ehrlich carcinoma in Swiss albino mice. Levans from two strains (ZAP and CP4) had the highest effects. NMR analysis showed that the polymers were composed only of fructose units. The results suggested that the antineoplasic effect is associated to the polysaccharide molecular weight and that a particular molecular weight range may be responsible for this effect. |
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