Oral vaccination of skunks with raccoon poxvirus recombinants expressing the rabies glycoprotein or the nucleoprotein. |
| |
| Authors: | M Fekadu J H Shaddock J W Sumner D W Sanderlin J C Knight J J Esposito G M Baer |
| |
| Affiliation: | Viral and Rickettsial Zoonoses Branch, Centers for Disease Control, Atlanta, Georgia 30333. |
| |
| Abstract: | Twenty nine skunks (Mephitis mephitis) were vaccinated orally with raccoon poxvirus (RCN) recombinants: 10 with a recombinant expressing the rabies virus glycoprotein (RCNRG), 10 with RCNRG mixed with a recombinant expressing the rabies virus nucleoprotein (RCNRN) and nine with RCN alone. Rabies virus neutralizing antibodies were detected in six of the 20 skunks; five skunks (three given RCNRG, two given a mixture of recombinants) survived a rabies challenge that was lethal for nine skunks vaccinated with RCN alone. |
| |
| Keywords: | |
|
|
