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Mathematical model of the activation of prothrombin by factor X a and factor V t |
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| Authors: | W Liniger G Karreman R Rawala R Colman |
| Institution: | (1) Thomas J. Watson Research Center, 10598 Yorktown Heights, NY, U.S.A.;(2) The Bockus Institute, Graduate Hospital, University of Pennsylvania, 19146 Philadelphia, PA, U.S.A.;(3) Department of Physiology, University of Pennsylvania, 19146 Philadelphia, PA, U.S.A.;(4) The Section of Hematology/Oncology, Temple University, 19140 Philadelphia, PA, U.S.A.;(5) Thrombosis Center, Temple University, 19140 Philadelphia, PA, U.S.A. |
| Abstract: | A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases. |
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