Stroke risk associated with balloon based catheter ablation for atrial fibrillation: Rationale and design of the MACPAF Study |
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| Authors: | Karl Georg Haeusler Lydia Koch Juliane Ueberreiter Matthias Endres Heinz-Peter Schultheiss Peter U Heuschmann Alexander Schirdewan Jochen B Fiebach |
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| Affiliation: | 1.Department of Neurology,Charité - University Medicine Berlin,Germany;2.Center for Stroke Research,Charité,Germany;3.Department of Cardiology and Pneumology,Charité - University Medicine Berlin,Germany |
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| Abstract: | Background Catheter ablation of the pulmonary veins has become accepted as a standard therapeutic approach for symptomatic paroxysmal atrial fibrillation (AF). However, there is some evidence for an ablation associated (silent) stroke risk, lowering the hope to limit the stroke risk by restoration of rhythm over rate control in AF. The purpose of the prospective randomized single-center study "Mesh Ablator versus Cryoballoon Pulmonary Vein Ablation of Symptomatic Paroxysmal Atrial Fibrillation" (MACPAF) is to compare the efficacy and safety of two balloon based pulmonary vein ablation systems in patients with symptomatic paroxysmal AF. |
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