| Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code? |
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| 引用本文： | Grosjean H,de Crécy-Lagard V,Björk GR. Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code?[J]. Trends in biochemical sciences, 2004, 29(10): 519-522. DOI: 10.1016/j.tibs.2004.08.005 |
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| 作者姓名： | Grosjean H de Crécy-Lagard V Björk GR |
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| 摘 要： | ![]()
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Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code? |
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| Grosjean Henri,de Crécy-Lagard Valérie,Björk Glenn R. Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code?[J]. Trends in biochemical sciences, 2004, 29(10): 519-522. DOI: 10.1016/j.tibs.2004.08.005 |
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| Authors: | Grosjean Henri de Crécy-Lagard Valérie Björk Glenn R |
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| Affiliation: | Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, F-91198 Gif-sur-Yvette, France. Grosjean@lebs.cnrs-gif.fr |
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| Abstract: | ![]()
The activation and charging of amino acids onto the acceptor stems of their cognate tRNAs are the housekeeping functions of aminoacyl-tRNA synthetases. The availability of whole genome sequences has revealed the existence of synthetase-like proteins that have other functions linked to different aspects of cell metabolism and physiology. In eubacteria, a paralog of glutamyl-tRNA synthetase, which lacks the tRNA-binding domain, was found to aminoacylate tRNA(Asp) not on the 3'-hydroxyl group of the acceptor stem but on a cyclopentene diol of the modified nucleoside queuosine present at the wobble position of anticodon loop. This modified nucleoside might be a relic of an ancient code. |
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