Protein tyrosine phosphatase PTP1B in cell adhesion and migration |
| |
| Authors: | Carlos O Arregui ángela González Juan E Burdisso Ana E González Wusener |
| |
| Affiliation: | Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (IIB-INTECH); Universidad Nacional de San Martín; Consejo Nacional de Investigaciones Científicas y Técnicas; Buenos Aires, Argentina |
| |
| Abstract: | Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support cell movement. The endoplasmic reticulum-bound protein tyrosine phosphatase PTP1B has been implicated as a regulator of cell adhesion and migration. Recent results from our laboratory shed light on potential mechanisms, such as Src/FAK signaling through Rho GTPases and integrin-cytoskeletal coupling. |
| |
| Keywords: | PTP1B Src adhesions cytoskeleton endoplasmic reticulum integrins migration α-actinin |
|
