Genetic background affects susceptibility to tumoral stem cell reprogramming |
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| Authors: | Idoia García-Ramírez Lucía Ruiz-Roca Alberto Martín-Lorenzo óscar Blanco María Bego?a García-Cenador Francisco Javier García-Criado Carolina Vicente-Due?as Isidro Sánchez-García |
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| Affiliation: | 1.Experimental Therapeutics and Translational Oncology Program; Instituto de Biología Molecular y Celular del Cáncer (IBMCC); CSIC/ Universidad de Salamanca; Salamanca, Spain;2.Institute of Biomedical Research of Salamanca (IBSAL); Salamanca, Spain;3.Pathology Deparment; University Hospital; Salamanca, Spain;4.Departamento de Cirugía; Universidad de Salamanca; Salamanca, Spain |
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| Abstract: | ![]()
The latest studies of the interactions between oncogenes and its target cell have shown that certain oncogenes may act as passengers to reprogram tissue-specific stem/progenitor cell into a malignant cancer stem cell state. In this study, we show that the genetic background influences this tumoral stem cell reprogramming capacity of the oncogenes using as a model the Sca1-BCRABLp210 mice, where the type of tumor they develop, chronic myeloid leukemia (CML), is a function of tumoral stem cell reprogramming. Sca1-BCRABLp210 mice containing FVB genetic components were significantly more resistant to CML. However, pure Sca1-BCRABLp210 FVB mice developed thymomas that were not seen in the Sca1-BCRABLp210 mice into the B6 background. Collectively, our results demonstrate for the first time that tumoral stem cell reprogramming fate is subject to polymorphic genetic control. |
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| Keywords: | cancer oncogenes tumoral reprogramming stem cells cancer therapy cancer stem cell mouse model |
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