Effects of chlorhexidine diacetate on Candida albicans, C. glabrata and Saccharomyces cerevisiae |
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| Authors: | Sarah J. Hiom J.R. Furr A.D. Russell J.R. Dickinson |
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| Affiliation: | Welsh School of Pharmacy;School of Pure and Applied Biology, University of Wales College of Cardiff, Cardiff, UK |
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| Abstract: | S.J. HIOM, J.R. FURR, A.D. RUSSELL AND J.R. DICKINSON, 1992. The effects of chlorhexidine diacetate (CHA) on Candida albicans, C. glabrata and wild-type and mannan, and permeability mutants of Saccharomyces cerevisiae have been studied. A CHA concentration of 10 μg/ml had little lethal activity against the Candida strains, but was more effective against S. cerevisiae. Concentrations of 100 and especially 1000 μg/ml brought about a much more rapid death of cells. 2-Mercaptoethanol enhanced the activity of CHA to some extent. Some of the mutant strains of S. cerevisiae were rather more sensitive than the wild-type strain. The age of cultures of C. albicans and C. glabrata influenced their response to CHA. |
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