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| 内生芬芳镰刀菌Dzf2中两个抗菌活性成分(英文) | |
| 引用本文： | 徐利剑,李培琴,赵江林,单体江,阴春晖,王明安,周立刚.内生芬芳镰刀菌Dzf2中两个抗菌活性成分(英文)[J].天然产物研究与开发,2010,22(4). |
| 作者姓名： | 徐利剑 李培琴 赵江林 单体江 阴春晖 王明安 周立刚 |
| 作者单位： | 1. 黑龙江大学农业资源与环境学院,哈尔滨,150000;中国农业大学农学与生物技术学院 2. 中国农业大学农学与生物技术学院 3. 中国农业大学理学院,北京,100193 |
| 摘 要： | 采用活性追踪的方法从盾叶薯蓣内生芬芳镰刀菌Dzf2中分离到两个抗菌活性成分,通过物理化学性质和波谱学特征鉴定为镰刀菌酸(1)和9,10-脱氢镰刀菌酸(2)。采用多孔板-MTT-比色法和孢子萌发法测定了化合物的抗菌活性。镰刀菌酸和9,10-脱氢镰刀菌酸对供试细菌的半抑制浓度(IC50)值为35.35μg/mL至171.29μg/mL;对稻瘟菌孢子萌发的IC50值分别为28.83μg/mL和27.06μg/mL。 |
| 关 键 词： | 内生真菌 芬芳镰刀菌 盾叶薯蓣 镰刀菌酸 10-脱氢镰刀菌酸 抗菌活性 |
Two Antimicrobial Compounds Fusaric Acid and 9,10-Dehydrofusaric Acid from Endophytic Fusarium redolens Dzf2 |
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| XU Li-jian,LI Pei-qin,ZHAO Jiang-lin,SHAN Ti-jiang,YIN Chun-hui,WANG Ming-an,ZHOU Li-gang.Two Antimicrobial Compounds Fusaric Acid and 9,10-Dehydrofusaric Acid from Endophytic Fusarium redolens Dzf2[J].Natural Product Research and Development,2010,22(4). | |
| Authors: | XU Li-jian LI Pei-qin ZHAO Jiang-lin SHAN Ti-jiang YIN Chun-hui WANG Ming-an ZHOU Li-gang |
| Abstract: | Two antimicrobial compounds were obtained by bioassayguided fractionation from the endophytic fungus Fusarium redolens Dzf2 from the medicinal plant Dioscorea zingiberensis.They were identified as fusaric acid(1) and 9,10dehydrofusaric acid(2) by physicochemical and spectral analysis.Antimicrobial activities of the two compounds were evaluated by multimicroplateMTT colorimetric assay and spore germination inhibition assay.Their median effective inhibitory concentration (IC50) values on test bacteria ranged from 35.35 μg/mL to 171.29 μg/mL,and those on the spore germination of Magnaporthe oryzae were 28.83 μg/mL for fusaric acid and 27.06 μg/mL for 9,10dehydrofusaric acid. |
| Keywords: | 9 endophytic fungus Fusarium redolens Dioscorea zingiberensis fusaric acid 9 10dehydrofusaric acid antimicrobial activity |
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