Speed-accuracy relationships during <em>in vitro</em> and <em>in vivo</em> protein biosynthesis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

*Speed-accuracy relationships during in vitro* and in vivo protein biosynthesis**

Authors:	Michael Laughrea

Affiliation:	Institut Lady Davis de Recherche Médicale, Sir Mortimer B. Davis - Jewish General Hospital, 3755 Côte Sainte Catherine, Montréal, Québec H3T 1E2, Canada

Abstract:

Keywords:	fidélité de traduction élongation streptomycine protéines ribosomales erreur de lecture chez les mammifères synthèse des protéines accuracy of translation elongation streptomycin ribosomal proteins misreading in mammalian systems protein synthesis poly U polyuridylic acid strAx ramA1 ribosomal ambiguity mutations in either ribosomal protein S4 or S5 resistance to streptomycin dependence on streptomycin the amount of material which in 1 ml would yield an absorbance of 1 at 260 nm in a 1 cm pathlength cell S 30 the supernatant recovered after centrifugation of a cell extract at 30,000 g for 30 min or so Phe phenylalanine S1–S21 the ribosomal proteins of the 30S subunit L1–L34 the ribosomal proteins of the 50S subunit Nea Neamine θ the association time of the A-site bound tRNA with the codon τ the characteristic time constant for amino-acid incorporation into a peptidyl-tRNA chain following codonaminoacyl-tRNA collision peptidyl-tRNA «dropping any displacement of the peptidyl-tRNA to a position which prevents further elongation
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