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C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis
Authors:Qiang Shao  Mei Yang  Chen Liang  Li Ma  Wei Zhang  Zhiwen Jiang
Institution:1. Center for Craniofacial Molecular Biology, University of Southern California , Los Angeles, CA, USA ORCID Iconhttps://orcid.org/0000-0001-5307-8264;2. Center for Craniofacial Molecular Biology, University of Southern California , Los Angeles, CA, USA;3. Center for Life Sciences, School of Life Sciences, Yunnan University , Kunming, P.R. China;4. Department of Cellular Biology, University of Georgia , Athens, GA, USA;5. Center for Craniofacial Molecular Biology, University of Southern California , Los Angeles, CA, USA;6. Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University , Dongguan, Guangdong, P.R. China
Abstract:
Keywords:C9orf72  lysosomal degradation  lysosomal exocytosis  macrophage  mice  MTORC1  SMCR8
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