The structural features of effective antagonists of the luteinizing hormone releasing hormone |
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Authors: | A Janecka T Janecki C Bowers K Folkers |
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Institution: | (1) Institute for Biomedical Research, The University of Texas at Austin, 78712 Austin, TX, USA;(2) Tulane University School of Medicine, New Orleans, Louisiana, USA |
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Abstract: | Summary The structure-activity data of 6 years on 395 analogs of the luteinizing hormone releasing hormone (LHRH) have been studied to determine effective substituents for the ten positions for maximal antiovulatory activity and minimal histamine release. The numbers of substituents studied in the ten positions are as follows: (41)1-(12)2-(12)3-(5)4-(47)5-(52)6-(16)7-(18)8-(4)9-(8)10. In position 1, DNal and DQal were effective with the former being more frequently the better substituent. DpClPhe was uniquely effective in position 2. Positions 3 and 4 are very sensitive to change. D3Pal in position 3 and Ser in position 4 of LHRH were in the best antagonists. PicLys and cPzACAla were the most successful residues in position 5 with cPzACAla being the better substituent. Position 6 was the most flexible and many substituents were effective; particularly DPicLys. Leu7 was most often present in the best antagonists. In position 8, Arg was effective for both antiovulatory activity and histamine release; ILys was effective for potency and lesser histamine release. Pro9 of LHRH was retained. DAlaNH2
10 was in the best antagonists.Abbreviations AABLys
N
-(4-acetylaminobenzoyl)lysine
- AALys
N
-anisinoyl-lysine
- AAPhe
3-(4-acetylaminophenyl)lysine
- Abu
2-aminobutyric acid
- ACLys
N
-(6-aminocaproyl)lysine
- ACyh
1-aminocyclohexanecarboxylic acid
- ACyp
1-aminocyclopentanecarboxylic acid
- Aile
alloisoleucine
- AnGlu
4-(4-methoxy-phenylcarbamoyl)-2-aminobutyric acid
- 2ANic
2-aminonicotinic acid
- 6ANic
6-aminonicotinic acid
- APic
6-aminopicolinic acid
- APh
4-aminobenzoic acid
- APhe
4-aminophynylalanine
- APz
3-amino-2-pyrazinecarboxylic acid
- Aze
azetidine-2-carboxylic acid
- Bim
5-benzimidazolecarboxylic acid
- BzLys
N
-benzoyllysine
- Cit
citrulline
- Cl2Phe
3-(3,4-dichlorphenyl)alanine
- cPzACAla
cis-3-(4-pyrazinylcarbonylaminocyclohexyl)alnine
- cPmACAla
cis-3-4-(4-pyrimidylcarbonyl)aminocyclohexyl]alanine
- Dbf
3-(2-dibenzofuranyl)alanine
- DMGLys
N
-(N,N-dimethylglycyl)lysine
- Dpo
N
-(4,6-dimethyl-2-pyrimidyl)-ornithine
- F2Ala
3,3-difluoroalanine
- hNal
4-(2-naphthyl)-2-aminobutyric acid
- HOBLys
N
-(4-hydroxybenzoyl)lysine
- hpClPhe
4-(4-chlorophenyl)-2-amino-butyric acid
- Hse
homoserine, 2-amino-4-hydroxybutanoic acid
- ICapLys
N
-(6-isopropylaminocaproyl)lysine
- ILys
N
-isopropyllysine
- Ind
indoline-2-carboxylic acid
- INicLys
N
-isonicotinoyllysine
- IOrn
N
-isopropylornithine
- Me3Arg
NG,NG,NG-trimethylarginine
- Me2Lys
N
,N
-dimethyllysine
- MNal
3-(6-methyl)-2-naphtyl]alanine
- MNicLys
N
-(6-methylpicolinoyl)lysine
- MPicLys
N
-(6-methylpicolinoyl)lysine
- MOB
4-methoxybenzoyl
- MpClPhe
N-methyl-3-(4-chlorphenyl)lysine
- MPZGlu
glutamic acid,-4-methylpiperazine
- Nal
3-(2-naphthyl)alanine
- Nap
2-naphthoic acid
- NicLys
N
-nicotinoyllysine
- NO2B
4-nitrobenzoyl
- NO2Phe
3-(4-nitrophenyl)alanine
- oClPhe
3-(2-chlorphenyl)alanine
- Opt
O-phenyl-tyrosine
- Pal
3-(3-pyridyl)alanine
- 2Pal
3-(2-pyridyl)alanine
- 2PALys
N
-(3-pyridylacetyl)lysine
- pCapLys
N
-(6-picolinoylaminocaproyl)lysine
- pClPhe
3-(4-chlorophenyl)alanine
- pFPhe
3-(4-fluorophenyl)-alanine
- Pic
picolinic acid
- PicLys
N
-picolinoyllysine
- Pip
piperidine-2-car-boxylic acid
- PmcLys
N
-(4-pyrimidylcarbonyl)lysine
- Ptf
3-(4-trifluromethyl phenyl)alanine
- Pz
pyrazinecarboxylic acid
- PzAla
3-pyrazinylalanine
- PzAPhe
3-(4-pyrazinylcarbonylaminophenyl)alanine
- Qal
3-(3-quinolyl)alanine
- Qnd-Lys
N
-quinaldoyllysine
- Qui
3-quinolinecarboxylic acid
- Qux
2-quinoxalinecarboxylic acid
- Tic
1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
- TinGly
2-thienylglycine
- tNACAla
trans-3-(4-nicotinoylaminocyclohexyl)-alanine
- tPACAla
trans-3-(4-picolinoylaminocyclohexyl)alanine |
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Keywords: | Amino acids LHRH antagonists Histamine release Structure-activity relationship |
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