Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis |
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| Authors: | Bo Zhang Jianxin Dai Huaqing Wang Huafeng Wei Jian Zhao Yajun Guo Kexing Fan |
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| Affiliation: | 1. International Joint Cancer Institute, The Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, People’s Republic of China;2. PLA General Hospital Cancer Center & PLA Cancer Research Institute, PLA Postgraduate School of Medicine, 28 Fuxing Road, Beijing, People’s Republic of China;3. National Engineering Research Center for Antibody Medicine and Shanghai Key Lab. of Cell Engineering and Antibody, 399 Libing Road, Shanghai 201203, People’s Republic of China |
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| Abstract: | Osteopontin (OPN) is abundant in mineralized tissues and has long been implicated in bone remodeling. However, the therapeutic effect of targeting OPN in bone loss diseases and the underlying molecular mechanism remain largely unknown. Here, we reported that anti-OPN mAb (23C3) could protect against ovariectomy-induced osteoporosis in mice, demonstrated by microcomputed tomography analysis and histopathology evaluation. In vitro assay showed that 23C3 mAb reduced osteoclasts (OCs)-mediated bone resorption through promotion of mature OC apoptosis. Thus, the study has important implications for understanding the role of OPN in OC bone resorption and survival, and OPN antagonists may have therapeutic potential for osteoporosis and other osteopenic diseases. |
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| Keywords: | Osteopontin Osteoclast survival Bone resorption Osteoporosis |
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