Cholecalciferol metabolites binding in porcine parathyroid glands. |
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| Authors: | J F Cloix A Ulmann M Bachelet J L Funck-Brentano |
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| Institution: | I.N.S.E.R.M. U.90 — Hôpital Necker — 161, rue de Sèvres — 75015 —Paris — France |
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| Abstract: | We studied the cytoplasmic and nuclear binding of 25-hydroxychole-calciferol and 1alpha,25-dihydroxycholecalciferol inside porcine parathyroid glands. Both sterols bind to cytoplasmic components, but a specific nuclear uptake was demonstrated only for 1alpha,25-dihydroxycholecalciferol. These findings support the hypothesis that mammalian parathyroid glands are a target organ for some cholecalciferol metabolites. |
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