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Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model |
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| Authors: | Shoji Seki Yumiko Asanuma-Abe Koichi Masuda Yoshiharu Kawaguchi Kunihiro Asanuma Carol Muehleman Akiko Iwai Tomoatsu Kimura |
| Institution: | (1) Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama Toyama, 930-0194, Japan;(2) Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA;(3) Department of Orthopaedic Surgery, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Mail Code 0863, La Jolla, CA 92093-0863, USA;(4) Department of Biochemistry, Rush Medical College at Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA |
| Abstract: | IntroductionThe etiology of degenerative disc disease is unknown. Several investigators have reported the presence of proteolytic enzymes, such as the matrix metalloproteinase (MMP) and ADAMTS (a disintegrin and metalloprotease with thrombospondin-like repeats) families, in degenerated human discs. Glasson and colleagues recently reported that a significant reduction occurs in the severity of cartilage destruction in ADAMTS5 knockout mice compared with wild-type mice. The purpose of this study was to evaluate the suppressive effects of injections of ADAMTS5 small interference RNA (siRNA) oligonucleotide on intervertebral disc degeneration in the rabbit anular needle-puncture model. |
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