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Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment
Authors:Mirella Georgouli  Cecilia Herraiz  Eva Crosas-Molist  Bruce Fanshawe  Oscar Maiques  Anna Perdrix  Pahini Pandya  Irene Rodriguez-Hernandez  Kristina M Ilieva  Gaia Cantelli  Panagiotis Karagiannis  Silvia Mele  Hoyin Lam  Debra H Josephs  Xavier Matias-Guiu  Rosa M Marti  Frank O Nestle  Jose L Orgaz  Victoria Sanz-Moreno
Institution:1. Barts Cancer Institute, John Vane Science Building, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK;2. Randall Centre for Cell and Molecular Biophysics, New Hunt’s House, Guy’s Campus, King’s College London, London SE1 1UL, UK;3. Department of Imaging Chemistry and Biology, Division of Imaging Sciences and Biomedical Engineering, St. Thomas Hospital, King’s College London, London SE1 7EH, UK;4. Tumour-Stroma Interactions in Cancer Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK;5. St John’s Institute of Dermatology, King’s College London and National Institute for Health Research Biomedical Research Centre at Guy’s and St Thomas’ Hospitals and King’s College London, London SE1 9RT, UK;6. Department of Oncology, Haematology and Stem Cell Transplantation, University Hospital of Hamburg Eppendorf, Hamburg 20246, Germany;7. Departments of Pathology Hospital U Arnau de Vilanova and Hospital U de Bellvitge, IRBLLEIDA, IDIBELL, University of Lleida, CIBERONC, Lleida, Spain;8. Department of Dermatology, Hospital U Arnau de Vilanova, IRBLLEIDA, University of Lleida, CIBERONC, Lleida, Spain;9. School of Cancer and Pharmaceutical Sciences, Guy’s Hospital, King’s College London, London SE1 9RT, UK
Abstract:
Keywords:ROCK-Myosin II  rounded-amoeboid melanoma cells  tumor invasive front  protein secretion  NF-κB  macrophages
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