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Dysfunctional CD8 T Cells Form a Proliferative,Dynamically Regulated Compartment within Human Melanoma
Authors:Hanjie Li  Anne M. van der Leun  Ido Yofe  Yaniv Lubling  Dikla Gelbard-Solodkin  Alexander C.J. van Akkooi  Marlous van den Braber  Elisa A. Rozeman  John B.A.G. Haanen  Christian U. Blank  Hugo M. Horlings  Eyal David  Yael Baran  Akhiad Bercovich  Aviezer Lifshitz  Ton N. Schumacher  Amos Tanay  Ido Amit
Affiliation:1. Department of Immunology, Weizmann Institute, Rehovot, Israel;2. Department of Molecular Oncology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands;3. Department of Computer Science and Applied Mathematics and Department of Biological Regulation, Weizmann Institute, Rehovot, Israel;4. Department of Surgical Oncology, Netherlands Cancer Institute—Antoni van Leeuwenhoek, Amsterdam, the Netherlands;5. Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands;6. Medical Oncology Department, Netherlands Cancer Institute—Antoni van Leeuwenhoek, Amsterdam, the Netherlands;7. Department of Pathology, Netherlands Cancer Institute—Antoni van Leeuwenhoek, Amsterdam, the Netherlands
Abstract:
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  • Keywords:T cell dysfunction  melanoma  single-cell RNA-seq  tumor microenvironment  tumor reactivity  immunotherapy  immune checkpoints  immunology  tumor immunology
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