A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele |
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| Authors: | Tsuyoshi Koide Kazuo Moriwaki Kikue Uchida Akihiko Mita Tomoko Sagai Hiromichi Yonekawa Hideki Katoh Nobumoto Miyashita Kimiyuk Tsuchiya Toennes J Nielsen Toshihiko Shiroishi |
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| Institution: | (1) Mammalian Genetics Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka-ken 411, Japan, JP;(2) The Graduate University for Advanced Studies, Hayama, Kanagawa-ken, 240-01, Japan, JP;(3) Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Honkomagome, Tokyo 113, Japan, JP;(4) Central Institute for Experimental Animals, Miyamae-ku, Kawasaki 216, Japan, JP;(5) Experimental Animal Center, Kagawa Medical University, Miki-cho, Kagawa-ken, 761-07, Japan, JP;(6) Experimental Animal Center, Miyazaki Medical College, Kiyotake, Miyazaki-ken 889-16, Japan, JP;(7) University of Aarhus, Mollers Alle 130, DK-8000 Aarhus C, Denmark, DK |
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| Abstract: | A new inbred strain JF1 (Japanese Fancy Mouse 1) was established from a strain of fancy mouse. Morphological and genetical
analysis indicated that the mouse originated from the Japanese wild mouse, Mus musculus molossinus. JF1 has characteristic coat color, black spots on the white coat, with black eyes. The mutation appeared to be linked to
an old mutation piebald (s). Characterization of the causative gene for piebald, endothelin receptor type B (ednrb), demonstrated that the allele in JF1 is same as that of classic piebald allele, suggesting an identical origin of these
two mutants. Possibly, classic piebald mutation was introduced from the Japanese tame mouse, which was already reported at
the end of the 1700s. We showed that JF1 is a useful strain for mapping of mutant genes on laboratory strains owing to a high
level of polymorphisms in microsatellite markers between JF1 and laboratory strains. The clarified genotypes of JF1 for coat
color are ``aa BB CC DD ss'.
Received: 30 May 1997 / Accepted: 26 August 1997 |
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