The p38 Pathway Regulates Oxidative Stress Tolerance by Phosphorylation of Mitochondrial Protein IscU |
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| Authors: | Lili Tian Jianming Chen Mingliang Chen Chloe Gui Chuan-qi Zhong Lixin Hong Changchuan Xie Xiurong Wu Lirong Yang Vakil Ahmad Jiahuai Han |
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| Affiliation: | From the ‡State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.;the §Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration (SOA), Xiamen, Fujian 361005, China, and ;the ¶Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada |
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| Abstract: | ![]()
The p38 pathway is an evolutionarily conserved signaling pathway that responds to a variety of stresses. However, the underlying mechanisms are largely unknown. In the present study, we demonstrate that p38b is a major p38 MAPK involved in the regulation of oxidative stress tolerance in addition to p38a and p38c in Drosophila. We further show the importance of MK2 as a p38-activated downstream kinase in resistance to oxidative stresses. Furthermore, we identified the iron-sulfur cluster scaffold protein IscU as a new substrate of MK2 both in Drosophila cells and in mammalian cells. These results imply a new mechanistic connection between the p38 pathway and mitochondria iron-sulfur clusters. |
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| Keywords: | Iron-Sulfur Protein Mitochondrial Aconitase Oxidative Stress p38 p38 MAPK |
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